標(biāo)題：Regioselective Pyridine C-H-Functionalization and Skeletal Editing
報(bào)告時(shí)間：2025年9月23日(星期二) 15:00-15:55
報(bào)告地點(diǎn)：人民大街校區(qū)化學(xué)學(xué)院第三教室
主講人：Armido Studer
主辦單位：化學(xué)學(xué)院
報(bào)告內(nèi)容簡(jiǎn)介：
Pyridines belong to the most abundant heteroarenes in medicinal chemistry and in agrochemical industry. In the lecture, highly regioselective pyridine C-H functionalization through a dearomatization/rearomatization sequence will be discussed. The dearomatized oxazino pyridines can be easily prepared on a large scale, and meta-functionalization becomes achievable through light-initiated radical alkylation and ionic transformations. As example, using such an approach meta-fluorinated pyridines are readily accessible. The same intermediates upon protonation to give the corresponding pyridinium salts also allow the highly regioselective radical Minisci para-alkylation. In addition, Cu-catalyzed meta-arylation and switchable radical para/meta-difluoromethylation through such intermediates will be presented. Radical meta-nitration and ionic meta-hydroxylation work equally well through such intermediates. Finally, it will be shown that this dearomatization concept is also applicable to pyridine skeletal editing. Further, it will be discussed that an alternative radical dearomatization process can be used for C to N mutation in indoles and benzofurans.
主講人簡(jiǎn)介：
Armido Studer教授：現(xiàn)任德國(guó)明斯特大學(xué)有機(jī)化學(xué)正教授 (W3)，歐洲科學(xué)院院士、德國(guó)國(guó)家科學(xué)院院士和英國(guó)皇家化學(xué)會(huì)會(huì)士。以自由基化學(xué)為核心，系統(tǒng)開(kāi)展自由基反應(yīng)機(jī)理研究及相關(guān)應(yīng)用開(kāi)發(fā)，成果廣泛應(yīng)用于催化科學(xué)、有機(jī)合成方法學(xué)與先進(jìn)材料化學(xué)等前沿領(lǐng)域。通過(guò)發(fā)展“持續(xù)自由基效應(yīng)等理論，并提出“電子催化”新概念，課題組建立了自由基反應(yīng)在選擇性催化轉(zhuǎn)化及功能分子精準(zhǔn)合成中的新范式。在氮氧自由基化學(xué)方向取得多項(xiàng)突破，應(yīng)用于表面功能化修飾、生物大分子精準(zhǔn)偶聯(lián)及復(fù)雜天然產(chǎn)物高效合成。Studer教授在Nature、Science、Nat. Synth. Nat. Chem.等國(guó)際頂級(jí)期刊發(fā)表研究論文400余篇，曾獲阿道夫馮貝耶爾紀(jì)念獎(jiǎng)?wù)?2025)、Arthur C. Cope Late Carer Scholars Award (2022)和英國(guó)皇家化學(xué)會(huì)佩德勒獎(jiǎng) (2018)等榮譽(yù)稱(chēng)號(hào)。
