標(biāo)題： Reductive Dimetalation of Unsaturated Bonds
報(bào)告時(shí)間：2025年9月23日(星期二) 16:00-16:55
報(bào)告地點(diǎn)：人民大街校區(qū)化學(xué)學(xué)院第三教室
主講人： Hideki Yorimitsu
主辦單位：化學(xué)學(xué)院
報(bào)告內(nèi)容簡(jiǎn)介：
The reductive metalation of π bonds is a well-known reaction that typically leads to the formation of protonated products such as trans-alkenes and 1,4-cyclohexadienes via carbanions. However, the use of such reactions for non-protonative transformations has been limited due to the instability of radical anion or dianion intermediates. In this talk, I will discuss recent developments in the generation of carbanions by reductive metalation of unsaturated compounds in the presence of reduction-resistant electrophiles, aiming at adding values to simple unsaturated molecules by increasing molecular complexity.Specifically, I will focus on the use of trialkoxyboranes as reduction-resistant electrophiles that can trap carbanions via their vacant p orbitals. This approach enables stereoselective reductive diboration of a range of unsaturated compounds, including alkenes (Org. Lett. 2020, 22, 2303), alkynes (Bull. Chem. Soc. Jpn. 2020, 93, 1171), cyclopropanes (Synlett 2021, 32, 219), and arenes (Org. Lett. 2021, 23, 4613). Additionally, I will describe recent advances in reductive anti-dimagnesiation and dialumination of alkynes using Mg- and Al-based reduction-resistant electrophiles (Nat. Synth. 2023, 2, 162), as well as reductive borylmetalation of alkynes by using flow microreactors (Nat. Synth. 2024, 3, 192).
主講人簡(jiǎn)介：
Hideki Yorimitsu教授：1997年和2002年先后于日本京都大學(xué)獲學(xué)士學(xué)位和博士學(xué)位；2002-2003年在東京大學(xué)從事博士后研究；2003年至今分別在京都大學(xué)材料化學(xué)學(xué)院和化學(xué)學(xué)院先后擔(dān)任助理教授、副教授、正教授；2024年起擔(dān)任京都大學(xué)研究生院副院長(zhǎng)。研究方向包括：有機(jī)合成、金屬有機(jī)化學(xué)、碳負(fù)離子化學(xué)、過(guò)渡金屬催化、自由基化學(xué)、有機(jī)硫化學(xué)、芳化重構(gòu)先后獲得Japan Academy Medal、JSPS Prize、Negishi Award、Mukaiyama Award、The Young Scientists’Prize等多個(gè)獎(jiǎng)項(xiàng)。兼任日本化學(xué)學(xué)會(huì)有機(jī)化學(xué)分會(huì)執(zhí)行秘書(shū)和Synthesis雜志副主編。
